PCOS Awareness and Early Intervention

Increased Funding Needed

  • Perspectives on Polycystic Ovary Syndrome: Is Polycystic Ovary Syndrome Research Underfunded? – https://www.ncbi.nlm.nih.gov/pubmed/29092064

     

    • Our data suggest that PCOS research may be underfunded considering its prevalence, economic burden, metabolic morbidity, and negative impact on quality of life.

PCOS and Maternal-Fetal Health

  • Pregnancy complications in women with polycystic ovary syndrome – https://www.ncbi.nlm.nih.gov/pubmed/26117684

     

    • Women with PCOS exhibit a clinically significant increased risk of pregnancy complications compared with controls. Data which were not adjusted for BMI or other confounders demonstrated in PCOS a 3-4-fold increased risk of pregnancy-induced hypertension and pre-eclampsia, a 3-fold increased risk of gestational diabetes and 2-fold higher chance for premature delivery.

     

  • Fetal-maternal outcomes and complications in pregnant women with polycystic ovary syndrome – https://www.ncbi.nlm.nih.gov/pubmed/27310674

     

    • We found that women with PCOS are at greater risk of complications during pregnancy than healthy women, consistent with the results of earlier studies….Compared with healthy women, the women with PCOS were more likely to have a history of miscarriage (42.9% vs. 19.8% P=0.005) and undergo caesarean section (41.2% vs. 21.4%, P=0.019). They were also at increased risk of developing a complication (odds ratio 2.38, 95% CI: 1.05-5.38) or having multiple concurrent complications (odds ratio 8.27, 95% CI: 1.45-47.3)

     

  • Association between polycystic ovary syndrome and the risk of pregnancy complications: A PRISMA-compliant systematic review and meta-analysis – https://www.ncbi.nlm.nih.gov/pubmed/28002314

     

      • PCOS in pregnancy was associated with greater risk of gestational diabetes mellitus, preeclampsia, pregnancy-induced hypertension, preterm delivery, cesarean delivery, miscarriage, hypoglycemia, and perinatal death.

     

    • PCOS in pregnancy is associated with a significantly increased risk of adverse pregnancy, fetal, and neonatal outcomes.
  • Pregnancy complications in polycystic ovary syndrome patients. – https://www.ncbi.nlm.nih.gov/pubmed/25356655
  • Implications of polycystic ovary syndrome for pregnancy and for the health of offspring. – https://www.ncbi.nlm.nih.gov/pubmed/26000511

Cardiometabolic Dysfunction in PCOS

 

 

 

 

 

 

 

 

 

PCOS and Cancer Risk

Mental Health and Adolescent Specific PCOS Research

 

 

 

  • Suitability of the National Health Care Surveys to Examine Behavioral Health Services Associated with Polycystic Ovary Syndrome. – Polycystic ovary syndrome and psychiatric disorders: Co-morbidity and heritability in a nationwide Swedish cohort – https://www.ncbi.nlm.nih.gov/pubmed/27513883

     

    • Women with PCOS were still at a significantly increased risk for bulimia, schizophrenia, bipolar disorder, depressive and anxiety disorders, personality disorders…Significantly higher [adjusted odds ratios] were found for autism spectrum disorders ASD in both brothers and sisters of women with PCOS, and for depressive, anxiety, and schizophrenia spectrum disorders in the sisters only…Attempted suicide were 40% higher in women with PCOS and 16% higher in their unaffected sisters. Elevated risk in their siblings suggests shared familial factors between PCOS and psychiatric disorders. This study is an important first step towards identifying the underlying mechanisms for risk of psychiatric disorders in women with PCOS. Health professionals treating women with PCOS should be aware that these patients – as well as their family members – are important targets for mental health care.

Environmental Factors/Endocrine Disruptors/Socioeconomic Factors

Ethnic Based Guidelines Needed/Health Disparity

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